Sonic hedgehog (SHH) signaling improves the angiogenic potential of Wharton's jelly-derived mesenchymal stem cells (WJ-MSC).

Gabriela ZavalaCatalina P PrietoAndrea A VillanuevaVerónica Palma

Published in: Stem cell research & therapy (2017)

WJ-MSC are a cell population responsive to SHH pathway stimulation. Basal SHH signaling is in part responsible for the angiogenic inductive properties of WJ-MSC. Overall, exogenous activation of the SHH pathway enhances the angiogenic properties of WJ-MSC, making this cell population an ideal target for treating tissue injury.

Keyphrases

single cell
cell therapy
stem cells
cancer therapy
risk assessment
climate change