Genetic landscape and immune mechanism of monocytes associated with the progression of acute-on-chronic liver failure.
Jia YaoTian LiuQiang ZhaoYaqiu JiJinjia BaiHan WangRuoyu YaoXiaoshuang ZhouYu ChenJun XuPublished in: Hepatology international (2023)
We present the accurate classification, molecular markers, and signaling pathways of monocytes associated with ACLF progression. Therapies targeting pro-inflammatory monocytes may be a promising approach for blocking ACLF progression.
Keyphrases
- liver failure
- hepatitis b virus
- dendritic cells
- peripheral blood
- signaling pathway
- deep learning
- machine learning
- gene expression
- drug induced
- single cell
- mass spectrometry
- respiratory failure
- epithelial mesenchymal transition
- copy number
- dna methylation
- intensive care unit
- pi k akt
- cell proliferation
- aortic dissection