Multivariate data analysis identifies natural clusters of Tuberous Sclerosis Complex Associated Neuropsychiatric Disorders (TAND).

Petrus J de VriesLoren LeclezioSugnet Gardner-LubbeDarcy KruegerMustafa SahinSteven SparaganaLiesbeth De WaeleAnna Jansen

Published in: Orphanet journal of rare diseases (2021)

Our findings identified a data-driven set of natural TAND clusters from within highly variable TAND Checklist data. The seven natural TAND clusters could be used to train families and professionals and to develop tailored approaches to identification and treatment of TAND. Natural TAND clusters may also have differential aetiological underpinnings and responses to molecular and other treatments.

Keyphrases

data analysis
genome wide
gene expression
dna methylation
mass spectrometry
single molecule
smoking cessation
high resolution