The PML hub: An emerging actor of leukemia therapies.
Domitille RérolleHugues de ThéPublished in: The Journal of experimental medicine (2023)
PML assembles into nuclear domains that have attracted considerable attention from cell and cancer biologists. Upon stress, PML nuclear bodies modulate sumoylation and other post-translational modifications, providing an integrated molecular framework for the multiple roles of PML in apoptosis, senescence, or metabolism. PML is both a sensor and an effector of oxidative stress. Emerging data has demonstrated its key role in promoting therapy response in several hematological malignancies. While these membrane-less nuclear hubs can enforce efficient cancer cell clearance, their downstream pathways deserve better characterization. PML NBs are druggable and their known modulators may have broader clinical utilities than initially thought.
Keyphrases
- oxidative stress
- dna damage
- squamous cell carcinoma
- endoplasmic reticulum stress
- small molecule
- bone marrow
- stem cells
- papillary thyroid
- working memory
- single cell
- cell death
- electronic health record
- cell therapy
- ischemia reperfusion injury
- endothelial cells
- single molecule
- induced apoptosis
- signaling pathway
- data analysis