The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, like ketamine, elicit rapid-acting antidepressant activity in the rat chronic mild stress model via cortical mechanisms.

Mariusz PappPiotr GrucaEwa LitwaMagdalena LasonAdrian Newman-Tancredi Ronan Depoortère

Published in: Journal of psychopharmacology (Oxford, England) (2024)

receptors constitutes a promising strategy to achieve RAAD effects, with additional benefits against cognitive deficits and anxiety in depressed patients, without ketamine's troublesome side effects.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
pain management
prognostic factors
peritoneal dialysis
sleep quality
bipolar disorder
quantum dots
patient reported