The association of brain-derived neurotrophic factor with the diagnosis and treatment response in depression.

Matea Nikolac PerkovicMartin GredicakMarina SagudGordana Nedic ErjavecSuzana UzunNela Pivac

Published in: Expert review of molecular diagnostics (2023)

BDNF has an important role in the pathophysiology and treatment response in depression. Most data reveal that peripheral BDNF levels are lower before than after antidepressant treatment and might be used as potential biomarkers of therapeutic response. Novel therapeutic strategies should target restoring/increasing BDNF levels.

Keyphrases

stress induced
depressive symptoms
sleep quality
electronic health record
genome wide
big data
single cell
deep learning
replacement therapy