Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for Pathogenicity.

Mizanur RahmanMartin IrmlerSandeep Keshavan Micol Introna Johannes BeckersLena PalmbergGunnar Johanson Koustav GangulySwapna Upadhyay

Published in: Viruses (2021)

In conclusion, we observed a typical anti-viral response in the bronchial model and a pro-fibrotic response in the alveolar model. The bro-ALI and alv-ALI models may serve as an easy and robust platform for assessing the pathogenicity of SARS-CoV-2 variants of concern at different lung regions.

Keyphrases

sars cov
respiratory syndrome coronavirus
endothelial cells
biofilm formation
systemic sclerosis
high throughput
idiopathic pulmonary fibrosis
staphylococcus aureus
pseudomonas aeruginosa
pulmonary fibrosis