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In silico comparison of pharmacokinetic properties of three extended half-life factor IX concentrates.

Tim PreijersLaura BukkemsMax van SpenglerFrank LeebeekMarjon CnossenRon A A Mathot
Published in: European journal of clinical pharmacology (2021)
When comparing EHL products, not only half-life but also exposure must be considered. In addition, variation in extravascular distribution of the FIX concentrates must be taken into account. This study provides insight into the different PK properties of these concentrates and may aid in determination of dosing regimens of EHL-FIX concentrates in real-life.
Keyphrases
  • molecularly imprinted