Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma.

Quanli ZhangRun ShiYongkang BaiLijuan MengJingwen HuHongyu ZhuTongyan LiuXiaomeng DeSiwei WangJie WangLin XuGuoren ZhouRong Yin

Published in: Cancer communications (London, England) (2021)

MND1, KLF6, and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD. MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients.

Keyphrases

cell cycle
cell proliferation
transcription factor
end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
signaling pathway
peritoneal dialysis