Incorporating variable RBE in IMPT optimization for ependymoma.
Hadis Moazami GoudarziGino J LimDavid GrosshansRadhe MohanWenhua CaoPublished in: Journal of applied clinical medical physics (2023)
We demonstrated the feasibility of directly incorporating variable RBE models in IMPT optimization. A hybrid RBE optimization strategy showed potential for clinical implementation by maintaining all current dose limits and reducing the incidence of high RBE in critical normal tissues in ependymoma patients.