The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
Céline AmadoriYme Ubeles van der VeldenDamien BonnardIgor OrlovNikki van BelErwann Le RouzicLaia MirallesJulie BriasFrancis ChevreuilDaniele SpehnerSophie ChassetBenoit LedoussalLuzia MayrFrançois MoreauFelipe GarcíaJosé GatellAlessia ZamborliniStéphane EmilianiMarc RuffBruno P KlaholzChristiane MoogBen BerkhoutMontserrat PlanaRichard BenarousPublished in: Retrovirology (2017)
Although strongly defective in infectivity, HIV-1 virions produced in the presence of the MUT-A INLAI have a normal protein and genomic RNA content as well as B and T cell immunoreactivities comparable to non-treated HIV-1. These inactivated viruses might form an attractive new approach in vaccine research in an attempt to study if this new type of immunogen could elicit an immune response against HIV-1 in animal models.