Effects of high-flow nasal cannula and non-invasive ventilation on inspiratory effort in hypercapnic patients with chronic obstructive pulmonary disease: a preliminary study.
Nuttapol RittayamaiPrapinpa PhuangchoeiJamsak TscheikunaNattakarn PraphruetkitLaurent BrochardPublished in: Annals of intensive care (2019)
Applying HFNC at 30 L/min for a short duration reduces inspiratory effort in comparison to 10 and 20 L/min, and resulted in similar effect than NIV delivered at modest levels of pressure support in hypercapnic COPD with mild to moderate exacerbation. Higher flow rates reduce respiratory rate but sometimes increase the effort to breathe. Using HFNC at 30 L/min in hypercapnic COPD patients should be further evaluated. Trial registration Thai Clinical Trials Registry, TCTR20160902001. Registered 31 August 2016, http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=2008 .
Keyphrases
- respiratory failure
- chronic obstructive pulmonary disease
- clinical trial
- extracorporeal membrane oxygenation
- end stage renal disease
- mechanical ventilation
- ejection fraction
- lung function
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- phase ii
- prognostic factors
- study protocol
- patient reported outcomes
- obstructive sleep apnea
- chronic rhinosinusitis
- clinical evaluation
- positive airway pressure