Risk factors for treatment-refractory and relapsed optic pathway glioma in children with neurofibromatosis type 1.
Chelsea KotchRobert AveryKelly D GetzEric BouffetPeter de BlankRobert ListernickDavid H GutmannMiriam BornhorstCynthia CampenGrant T LiuRichard AplencYimei LiMichael J FisherPublished in: Neuro-oncology (2022)
Young age, posterior tumor location, and optic disc abnormalities may identify patients with the greatest likelihood of refractory/relapsed NF1-OPG and poor visual outcomes, and who may benefit from newer treatment strategies.
Keyphrases
- acute lymphoblastic leukemia
- acute myeloid leukemia
- multiple myeloma
- hodgkin lymphoma
- diffuse large b cell lymphoma
- optical coherence tomography
- optic nerve
- young adults
- oxidative stress
- pi k akt
- lps induced
- nuclear factor
- type diabetes
- middle aged
- adipose tissue
- combination therapy
- inflammatory response
- glycemic control