Associations Between Blood-Based Biomarkers and Cognitive and Functional Trajectories Among Participants of the MEMENTO Cohort.

Leslie GrassetVincent BouteloupFederica CacciamaniIsabelle Pellegrin Vincent Planche Genevieve Chene Carole Dufouilnull null

Published in: Neurology (2024)

In a memory clinic sample, p-tau181 and NfL, both independently and jointly, are linked to more pronounced cognitive, physical and functional declines. Blood-based biomarker measurement in AD research may provide useful insights regarding biological processes underlying cognitive, physical, and functional declines in at-risk individuals.

Keyphrases

physical activity
mental health
primary care
depressive symptoms
cerebrospinal fluid