Effect of metformin on the high-density lipoprotein proteome in youth with type 1 diabetes.
Evgenia GourgariKristen J NadeauLaura PyleMartin P PlayfordJunfeng MaNehal N MehtaAlan T RemaleyScott M GordonPublished in: Endocrinology, diabetes & metabolism (2021)
Despite having little effect on HDL-C, metformin increased PGRP2 and A2MG protein on HDL in youth with T1D, but had no significant effect on CEC. Further studies are needed to understand the impact of PGRP2 and A2MG on other HDL functions.