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A Primary Kidney Giant Cell Tumor of Soft Tissue Caused Peritoneal Dissemination, Considered to Be Malignant Transformation: A Case Report.

Chiina HataYuki FukawaToru MotoiYuko KinowakiTakumi AkashiKenichi OhashiYudai IshikawaYuma WasedaYasuhisa FujiiRyota KakutaSadakatsu IkedaIichiroh Ohnishi
Published in: Diagnostics (Basel, Switzerland) (2023)
Giant cell tumor of soft tissue (GCTST) is a defined disease entity that has a morphology similar to giant cell tumor of bone (GCTB). The malignant transformation of GCTST has not been reported, and a kidney primary is extremely rare. We report the case of a 77-year-old Japanese male, who was diagnosed with primary GCTST of the kidney and showed peritoneal dissemination, considered to be a malignant transformation of GCTST, in 4 years and 5 months. Histologically, the primary lesion showed characteristics of round cells with not prominent atypia, multi-nucleated giant cells, and osteoid formation, and carcinoma components were not found. The peritoneal lesion was characterized by osteoid formation and round to spindle-shaped cells, but differed in nuclear atypia, and multi-nucleated giant cells were not detected. Immunohistochemical and cancer genome sequence analysis suggested these tumors were sequential. This is a first report of a case that we could diagnose as primary GCTST of the kidney and could be determined as malignant transformation of GCTST in the clinical course. Analysis of this case will be examined in the future when genetic mutations and the disease concepts of GCTST are established.
Keyphrases
  • giant cell
  • induced apoptosis
  • cell cycle arrest
  • soft tissue
  • cell death
  • squamous cell carcinoma
  • gene expression
  • young adults
  • pi k akt
  • data analysis