Association of Regular Opioid Use With Incident Dementia and Neuroimaging Markers of Brain Health in Chronic Pain Patients: Analysis of UK Biobank.
Yaqing GaoBinbin SuLei DingDanial QureshiShenda HongJie WeiChao ZengGuanghua LeiJunqing XiePublished in: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (2024)
Regular opioid use in chronic pain patients was associated with an increased risk of dementia and poorer brain health when compared to non-opioid analgesic use. These findings imply a need for re-evaluation of opioid prescription practices for chronic pain patients and, if further evidence supports causality, provide insights into strategies to mitigate the burden of dementia.
Keyphrases
- chronic pain
- end stage renal disease
- ejection fraction
- healthcare
- newly diagnosed
- chronic kidney disease
- pain management
- public health
- peritoneal dialysis
- prognostic factors
- cardiovascular disease
- mental health
- cognitive impairment
- patient reported outcomes
- emergency department
- risk assessment
- subarachnoid hemorrhage
- functional connectivity
- patient reported
- human health