Medial prefrontal cortical PPM1F alters depression-related behaviors by modifying p300 activity via the AMPK signaling pathway.

Jing LiuFantao MengWentao WangMin WuYu ZhangMinghu CuiChangyun QiuFengai HuDi ZhaoDan WangCuilan LiuDunjiang LiuZhicheng XuYameng WangWei LiChen Li

Published in: CNS neuroscience & therapeutics (2023)

Our findings demonstrate that PPM1F in the mPFC modulates depression-related behavioral responses by regulating the function of p300 via the AMPK signaling pathway.

Keyphrases

signaling pathway
depressive symptoms
pi k akt
skeletal muscle
epithelial mesenchymal transition
sleep quality
working memory
induced apoptosis
protein kinase
functional connectivity