CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2.

Huong Thi NguyenArfaxad Reyes-AlcarazHyo Jeong YongLan Phuong NguyenHee-Kyung ParkAsuka InoueCheol Soon LeeJae Young SeongJong-Ik Hwang

Published in: Cell & bioscience (2020)

This study demonstrates that SDF-1α-stimulated CXCR7 mediates β-arrestin2 recruitment via different molecular networking from that of CXCR4. CXCR7 may be neither a simple scavenger nor auxiliary receptor but plays an essential role in cell migration through cooperation with CXCR4.

Keyphrases

cell migration
binding protein