Clinical Calculator Based on Molecular and Clinicopathologic Characteristics Predicts Recurrence Following Resection of Stage I-III Colon Cancer.
Martin R WeiserMeier HsuPhilip S BauerWilliam C ChapmanIvan A GonzalezDeyali ChatterjeeDeepak LingamMatthew G MutchAjaratu KeshinroJinru ShiaEfsevia VakianiTsuyoshi KonishiYoshifumi ShimadaZsofia K StadlerNeil H SegalAndrea CercekLeonard B SaltzRona YaegerMarjorie G ZaudererMaria WidmarIris H WeiEmmanouil P PappouJ Joshua SmithGarrett NashPhilip B PatyJulio Garcia-AguilarMithat GönenPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
This third-generation clinical calculator for predicting cancer recurrence following curative colectomy successfully incorporates microsatellite genomic phenotype and the presence of tumor-infiltrating lymphocytes, resulting in improved discrimination and predictive accuracy. This exemplifies an evolution of a clinical calculator to maintain relevance by incorporating emerging variables as they become validated and accepted in the oncologic community.