Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction.

Helen Fogarty Soracha E Ward Liam Townsend Ellie Karampini Stephanie Elliott Niall Conlon Jean Dunne Rachel Kiersey Aifric Naughton Mary Gardiner Mary B Byrne Colm Bergin Jamie M O'Sullivan Ignacio Martín-Loeches Parthiban Nadarajan Ciaran Bannan Patrick W G Mallon Gerard F Curley Roger J S Preston Aisling M Rehill Ross Ian Baker Clíona Ní Cheallaigh James S O'Donnellnull null

Published in: Journal of thrombosis and haemostasis : JTH (2022)

Our data provide insights into sustained EC activation, dysregulated angiogenesis, and VWF/ADAMTS-13 axis imbalance in convalescent COVID-19. In keeping with the pivotal role of immunothrombosis in acute COVID-19, our findings support the hypothesis that abnormal T cell and monocyte populations may be important in the context of persistent EC activation and hemostatic dysfunction during convalescence.

Keyphrases

coronavirus disease
sars cov
oxidative stress
endothelial cells
respiratory syndrome coronavirus
liver failure
dendritic cells
respiratory failure
intensive care unit
big data
vascular endothelial growth factor
drug induced
machine learning
case report
peripheral blood
aortic dissection
data analysis