Has Deep Brain Stimulation Changed the Very Long-Term Outcome of Parkinson's Disease? A Controlled Longitudinal Study.
Philipp MahlknechtMarina PeballKatherina MairMario WerkmannMichael NockerElisabeth WolfWilhelm EisnerSweta BajajSebastian QuirbachCecilia PeraltaSabine EschlböckGregor K WenningPeter WilleitKlaus SeppiWerner PoewePublished in: Movement disorders clinical practice (2020)
Treatment with chronic subthalamic DBS was associated with lower risk for recurrent falls and psychotic symptoms, effects that may be mediated through improved motor symptom control and reduction in dopaminergic therapies, respectively. There was no evidence for DBS effects on underlying disease progression.