Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: an individual isolate meta-analysis.

Camus NimmoNeda BionghiMatthew J CummingsRubeshan PerumalMadeleine HopsonShamim Al JubaerAllison WolfBarun Mathema Michelle H Larsen Max R O'Donnell

Published in: medRxiv : the preprint server for health sciences (2023)

Sequencing candidate genes is insufficiently sensitive to diagnose clinical bedaquiline resistance, but where identified a limited number of mutations should be assumed to be associated with resistance. Genomic tools are most likely to be effective in combination with rapid phenotypic diagnostics.

Keyphrases

drug resistant
multidrug resistant
systematic review
single cell
meta analyses
emergency department
loop mediated isothermal amplification
copy number
gene expression
dna methylation
human immunodeficiency virus