USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells.
Aidan P McCannPeter SmythFrancesco CogoWilliam J McDaidLai JiangJia LinEmma EvergrenRoberta E BurdenSandra Van SchaeybroeckChristopher J ScottJames F BurrowsPublished in: Cell communication and signaling : CCS (2018)
Our data reveals that USP17 facilitates trafficking and oncogenic signaling of mutant EGFR and indicates targeting USP17 could represent a viable therapeutic strategy in NSCLC tumours carrying either an EGFR activating mutation, or a resistance gatekeeper mutation.
Keyphrases
- small cell lung cancer
- epidermal growth factor receptor
- advanced non small cell lung cancer
- tyrosine kinase
- brain metastases
- induced apoptosis
- transcription factor
- signaling pathway
- cell cycle arrest
- wild type
- electronic health record
- cancer therapy
- cell proliferation
- machine learning
- deep learning
- data analysis
- artificial intelligence