Dual receptor T cells mediate effective antitumor immune responses via increased recognition of tumor antigens.

Hyun J JangChristine CaronCalvin K LeeLu WangBurhan JamaJack D Bui Gerald P Morris

Published in: Journal for immunotherapy of cancer (2023)

These results discover an unrecognized role for dual TCR cells in protective immune function and identify these cells and their TCRs as a potential resource for antitumor immunotherapy.

Keyphrases

oxidative stress
induced apoptosis
immune response
cell cycle arrest
dendritic cells
regulatory t cells
cell death
signaling pathway
endoplasmic reticulum stress
cell proliferation