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Molecular mechanisms underlying the impact of mutations in SOD1 on its conformational properties associated with amyotrophic lateral sclerosis as revealed with molecular modelling.

Nikolay A AlemasovNikita V IvanisenkoSrinivasan RamachandranVladimir A Ivanisenko
Published in: BMC structural biology (2018)
The modelling highlights that both stability of the copper binding site and stability of the dimer can play an important role in ALS progression.
Keyphrases
  • amyotrophic lateral sclerosis
  • single molecule
  • molecular dynamics
  • molecular dynamics simulations
  • single cell
  • oxide nanoparticles