Biased agonism and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus-induced gene 2.

Viktorija DaugvilaiteChristian Medom MadsenMichael LückmannClara Castello EcheverriaAndreas Walter SailerThomas Michael FrimurerMette Marie RosenkildeTau Benned-Jensen

Published in: British journal of pharmacology (2017)

Collectively, our data point to N114 as a key residue for EBI2 signalling controlling the balance between G protein-dependent and -independent pathways and facilitating sodium binding.

Keyphrases

epstein barr virus
diffuse large b cell lymphoma
high glucose
small molecule
diabetic rats
electronic health record
copy number
genome wide
big data
drug induced
dna binding
gene expression
deep learning
artificial intelligence
data analysis
structural basis