The availability of the embryonic TGF-β protein Nodal is dynamically regulated during glioblastoma multiforme tumorigenesis.

Maria Cecília Oliveira-NunesSuzana Assad KahnAna Luiza de Oliveira BarbeitasTania Cristina Leite de Sampaio E SpohrLuiz Gustavo Feijó DuboisGrasiella Maria Ventura MatioszekWilliam QueridoLoraine CampanatiJosé Marques de Brito NetoFlavia Regina Souza LimaVivaldo Moura-NetoKatia Carneiro

Published in: Cancer cell international (2016)

Our results show for the first time that Nodal availability relates to GBM cell differentiation status and that it is dynamically regulated by an endocytic pathway during GBM tumorigenesis, shedding new light on molecular pathways that might emerge as putative targets for Nodal signaling in GBM therapy.

Keyphrases

neoadjuvant chemotherapy
lymph node
transcription factor
stem cells
radiation therapy
single molecule
small molecule
amino acid
locally advanced
cell therapy