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Establishing an economical and widely accessible donation after circulatory death animal abattoir model for lung research using ex vivo lung perfusion.

Zhang Long ZhangNiels MoeslundMichiel Andy HuRoland HoffmannLeonie Harmina VenemaCaroline Van De WauwerHidde J HaismaToshihiro OkamotoErik Alfons Maria VerschuurenHendrik Gerrit Derk LeuveninkHans EiskjærMichiel Elardus Erasmus
Published in: Artificial organs (2022)
Sheep lungs, acquired from an abattoir, can be ex vivo perfused under similar conditions as lab animal lungs with similar results regarding e.g., oxygenation and ATP restoration. Furthermore, costs can be significantly reduced by making use of this abattoir model. By increasing accessibility and lowering costs for experiments using lung perfusion, more results may be achieved in the field of lung diseases.
Keyphrases
  • magnetic resonance imaging
  • computed tomography
  • blood flow