Susceptibility to ERAP1 gene single nucleotide polymorphism modulates the inflammatory cytokine setting in ankylosing spondylitis.

Maryam HemmatzadehFarhad BabaieFatemeh EzzatifarFatemeh S MohammadiMehrdad EbrazehShirin Golabi AghdamMehrzad HajalilooGholamreza AziziArezoo Gowhari ShabgahNajibeh ShekariNasrin SehatiRamin HosseinzadehHamed MohammadiZohreh Babaloo

Published in: International journal of rheumatic diseases (2019)

This study demonstrated the association of ERAP1 gene rs27038 polymorphism with the risk of AS in an Iranian population. Additionally, it seems that rs27038 is involved in the modulation of the inflammatory IL-17/IL-23 axis in AS.

Keyphrases

ankylosing spondylitis
copy number
genome wide
oxidative stress
rheumatoid arthritis
disease activity
genome wide identification
gene expression
systemic lupus erythematosus
dna methylation