Discovery of antipsychotic loxapine derivatives against intracellular multidrug-resistant bacteria.
Hsueh-Chun LinYi-Lun WuCheng-Yun HsuMan-Yi LinLing-Han ChenChung-Wai ShiauHao-Chieh ChiuPublished in: RSC medicinal chemistry (2022)
The emergence and spread of multidrug-resistant bacteria highlight the need for new antibacterial interventions. A screening of 24 newly synthesized dibenzoxazepines identified a small molecule compound, SW14, with potent inhibitory activity against intracellular multidrug-resistant and fluoroquinolone-resistant strains of S. typhimurium in macrophages and epithelial cells. Moreover, intra-macrophagic Salmonella typhi , Yersinia enterocolitica , and Listeria monocytogenes and methicillin-resistant Staphylococcus aureus are also susceptible to SW14. Overall, our findings suggest that SW14 has a broad-spectrum activity against intracellular bacteria.
Keyphrases
- multidrug resistant
- listeria monocytogenes
- small molecule
- methicillin resistant staphylococcus aureus
- drug resistant
- gram negative
- acinetobacter baumannii
- klebsiella pneumoniae
- reactive oxygen species
- escherichia coli
- staphylococcus aureus
- protein protein
- physical activity
- anti inflammatory
- high throughput
- pseudomonas aeruginosa
- cystic fibrosis