Evaluating and improving real-world evidence with Targeted Learning.
Susan GruberRachael V PhillipsHana LeeJohn ConcatoMark van der LaanPublished in: BMC medical research methodology (2023)
Before RWE can be used in support of clinical and regulatory decision-making, its quality and reliability must be systematically evaluated. The TL roadmap prescribes how to carry out a thorough, transparent, and realistic assessment of RWE. We recommend this approach be a routine part of any decision-making process.