Bone Muscle Crosstalk in Spinal Cord Injuries: Pathophysiology and Implications for Patients' Quality of Life.
Marco InvernizziAlessandro de SireStefano CardaKonstantinos VenetisFilippo RenòCarlo CisariNicola FuscoPublished in: Current osteoporosis reports (2021)
Several studies attempted to describe the biology underpinning the links between bone and muscle tissues in the setting of highly disabling conditions, such as osteoporosis, sarcopenia, and neurodegenerative disorders, although these bidirectional connections remain still unclear. SCI could be considered an in vivo paradigmatic model of the bone muscle interactions in unloading conditions that might be expanded in the field of neurodegenerative disorders or cancer studies. Future studies should take into consideration the newer insights into bone muscle crosstalk in order to develop multitargeted and therapeutic interventions.
Keyphrases
- bone mineral density
- skeletal muscle
- spinal cord
- postmenopausal women
- soft tissue
- end stage renal disease
- bone loss
- bone regeneration
- spinal cord injury
- case control
- ejection fraction
- chronic kidney disease
- newly diagnosed
- body composition
- gene expression
- physical activity
- squamous cell carcinoma
- papillary thyroid
- peritoneal dialysis
- squamous cell
- prognostic factors
- young adults
- patient reported