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Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis.

Stefania RaimondoLaura SaievaEmanuela VicarioMarzia PucciDenise ToscaniMauro MannoSamuele RaccostaNicola GiulianiRiccardo Alessandro
Published in: Journal of hematology & oncology (2019)
In conclusion, our data indicate that AREG is packed into MM-derived exosomes and implicated in OC differentiation through an indirect mechanism mediated by OBs.
Keyphrases
  • growth factor
  • stem cells
  • mesenchymal stem cells
  • multiple myeloma
  • bone loss
  • bone mineral density
  • electronic health record
  • big data
  • lps induced
  • body composition
  • inflammatory response
  • bone regeneration