Fc-Silent Anti-TIGIT Antibodies Potentiate Antitumor Immunity without Depleting Regulatory T Cells.

Dana Piovesan Amber E de Groot Soonweng Cho Amy E Anderson Rebecca D Ray Amita Patnaik Paul G Foster Casey G Mitchell Alejandra Y Lopez Espinoza Wandi S Zhu Carlo E Stagnaro Hema Singh Xiaoning Zhao Lisa Seitz Nigel P C Walker Matthew J Walters Kelsey E Sivick

Published in: Cancer research (2024)

Fcs-silent anti-TIGIT antibodies enhance the activation of tumor-specific pre-exhausted T cells and promote antitumor efficacy without depleting T regulatory cells.

Keyphrases

regulatory t cells
induced apoptosis
dendritic cells
cell cycle arrest
transcription factor
endoplasmic reticulum stress
oxidative stress
immune response
cell death
cell proliferation