Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study.

Ferdinando ClarelliAndrea CoronaKimmo PääkkönenMelissa SorosinaAlen ZolloFredrik PiehlTomas OlssonPernilla StridhMaja JagodicBernhard HemmerChristiane GasperiAdil HarroudKlementy ShchetynskyAlessandra MingioneElisabetta MasciaKaalindi MisraAntonino GiordanoMaria Laura Terzi MazzieriAlberto PrioriJanna SaarelaIngrid KockumMassimo FilippiFederica EspositoFilippo Giovanni Martinelli Boneschi

Published in: Journal of neurology (2024)

This GWAS, the largest pharmacogenomic study of response to NTZ, suggested MS-implicated genes and Wnt/β-catenin signaling pathway, an essential component for blood-brain barrier formation and maintenance, to be related to treatment response.

Keyphrases

multiple sclerosis
blood brain barrier
genome wide
stem cells
dna methylation
mass spectrometry
ms ms
gene expression
white matter
clinical decision support
copy number