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Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells.

Alexander CalderonTamara MestvirishviliFrancesco BoccalatteKelly V RugglesGregory David
Published in: Epigenetics & chromatin (2024)
Our findings provide new insights into controlled cell cycle progression as a potential regulator of HSC lineage commitment through the modulation of chromatin features.
Keyphrases
  • cell cycle
  • stem cells
  • transcription factor
  • cell proliferation
  • dna damage
  • gene expression
  • genome wide
  • bone marrow
  • cell therapy
  • histone deacetylase
  • dna methylation
  • oxidative stress
  • human health
  • climate change