Molecular Mechanisms of Glial Cells Related Signaling Pathways Involved in the Neuroinflammatory Response of Depression.
Junhui WangJie QinPeng WangYu SunQi ZhangPublished in: Mediators of inflammation (2020)
Dysfunction of the glial cells, such as astrocytes and microglia, is one of the pathological features in many psychiatric disorders, including depression, which emphasizes that glial cells driving neuroinflammation is not only an important pathological change in depression but also a potential therapeutic target. In this review, we summarized a recent update about several signaling pathways in which glial cells may play their roles in depression through neuroinflammatory reactions. We focused on the basic knowledge of these signaling pathways by elaborating each of them. This review may provide an updated image about the recent advances on these signaling pathways that are essential parts of neuroinflammation involved in depression.
Keyphrases
- induced apoptosis
- signaling pathway
- cell cycle arrest
- depressive symptoms
- endoplasmic reticulum stress
- pi k akt
- neuropathic pain
- oxidative stress
- sleep quality
- traumatic brain injury
- epithelial mesenchymal transition
- inflammatory response
- machine learning
- cell proliferation
- lipopolysaccharide induced
- spinal cord injury
- physical activity
- lps induced
- brain injury
- human health