Elevated methemoglobin levels in patients treated with hydroxocobalamin: a case series and in-vitro analysis.

Emily Anne Kiernan Joseph E CarpenterCamille A DunkleyTim P MoranLindsay Schaack RothsteinElizabeth SilverMaryam SalehiDavid D KochBrent W MorganBrian Patrick Murray

Published in: Clinical toxicology (Philadelphia, Pa.) (2022)

We observed a noteworthy temporal association between the formation of methemoglobinemia and the administration of hydroxocobalamin. This does not appear to be an artifact of the CO-oximeters. This could have profound implications for patients who are already hypoxemic or have impaired oxygen carrying capacity from carboxyhemoglobin.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
patient reported outcomes
intensive care unit
mechanical ventilation