lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth.

Haobo LiLena E TragerXiaojun LiuMargaret H HastingsChunyang XiaoJustin Baldovino GuerraSamantha ToGuoping LiAshish YeriRodosthenis RodosthenousMichael G Silverman Saumya Das Amrut V Ambardekar Michael R BristowJuan Manuel González-RosaAnthony Rosenzweig

Published in: Circulation (2022)

These studies identify lncExACT1-DCHS2 as a novel pathway regulating cardiac hypertrophy and cardiomyogenesis. lncExACT1-DCHS2 acts as a master switch toggling the heart between physiological and pathological growth to determine functional outcomes, providing a potentially tractable therapeutic target for harnessing the beneficial effects of exercise.

Keyphrases

heart failure
high intensity
physical activity
big data
machine learning
case control