Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection.

Terry ZhouNora J GilliamSizhen LiSimone SpaudauRaven M OsbornChristopher S AndersonThomas J MarianiJuilee ThakarStephen DewhurstDavid H MathewsLiang HuangYan Sun

Published in: bioRxiv : the preprint server for biology (2022)

DVGs during natural SARS-CoV-2 infection. These findings set up the foundation for further mechanism studies of SARS-CoV-2 recombination and provide the evidence to harness DVGsâ€™ immunostimulatory potential in the development of vaccine and antivirals for SARS-CoV-2.

Keyphrases

sars cov
respiratory syndrome coronavirus
dna damage
dna repair
case control
risk assessment