Efficacy of probiotics in the prevention of diarrhea in ventilated critically ill ICU patients: meta-analysis of randomized control trials.
Kentaro ShimizuTomoya HiroseHiroshi OguraPublished in: Journal of intensive care (2021)
We comment on the study by Batra et al. on the efficacy of probiotics in the prevention of ventilator-associated pneumonia in critically ill ICU patients. They also reported that probiotics administration was not associated with a statistically significant reduction in the incidence of diarrhea (OR 0.59; CI 0.34, 1.03; P = 0.06; I 2 = 38%). However, their meta-analysis missed one RCT, and when we repeated the analysis including this RCT, we found that probiotics administration significantly reduced the incidence of diarrhea (OR 0.51; CI 0.28, 0.92; P = 0.02; I 2 = 45.6%). We thus believe that probiotics administration is effective in reducing the incidence of diarrhea in ventilated critically ill ICU patients.
Keyphrases
- end stage renal disease
- systematic review
- intensive care unit
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- clinical trial
- irritable bowel syndrome
- patient reported outcomes
- acute respiratory distress syndrome
- meta analyses
- study protocol
- double blind
- case control
- placebo controlled
- phase ii
- community acquired pneumonia