Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma.

Jennifer TeichmanLorin DodbibaHenry ThaiAndrew FleetTrevor MoreyLucy LiuMadison McGregorDangxiao ChengZhuo ChenGail DarlingYonathan BrhaneYuyao SongOsvaldo Espin-GarciaWei XuHala GirgisJoerg SchwockHelen MacKayRobert BristowLaurie AillesGeoffrey Liu

Published in: PloS one (2018)

Hh signaling mediates the radiation response in some EAC PDX models, and inhibition of this pathway may augment the efficacy of radiation in tumours that are Hh dependent.

Keyphrases

endothelial cells
radiation induced
squamous cell carcinoma
radiation therapy
locally advanced
rectal cancer