Towards More Robust Evaluation of the Predictive Performance of Physiologically Based Pharmacokinetic Models: Using Confidence Intervals to Support Use of Model-Informed Dosing in Clinical Care.
Marjolein D van BorselenLaurens Auke Æmiel SluijtermanRick GreupinkSaskia N de WildtPublished in: Clinical pharmacokinetics (2024)
With this method, we aim to provide a tool to further increase confidence in PBPK model performance and facilitate its use for directly informing drug dosing in clinical care.