Genomic profile of MYCN non-amplified neuroblastoma and potential for immunotherapeutic strategies in neuroblastoma.

Eunjin LeeJi Won LeeBoram LeeKyunghee ParkJoonho ShimKeon Hee YooHong Hoe KooKi Woong SungWoong-Yang Park

Published in: BMC medical genomics (2020)

This study provides novel insights into the genomic background of MYCN non-amplified NB. Activation of immune-related pathways in the high-risk group and the results of TMB and mutational signature analyses collectively suggest the need for further investigation to discover potential immunotherapeutic strategies for NB.

Keyphrases

human health
gene expression
risk assessment
genome wide