Development of a deep-learning model tailored for HER2 detection in breast cancer to aid pathologists in interpreting HER2-low cases.

Pierre-Antoine BannierGlenn BroeckxLoïc HerpinRémy DuboisLydwine Van PraetCharles MaussionFrederik DemanEllen AmonooAnca MeraJasmine TimbresCheryl GillettElinor SawyerPatrycja GazińskaPiotr ZiolkowskiMagali Lacroix-TrikiRoberto SalgadoSheeba Irshad

Published in: Histopathology (2024)

Deep learning can support pathologists' interpretation of difficult HER2-low cases. Morphological variables and some specific artefacts can cause discrepant HER2-scores between the pathologist and the DL model.

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