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Tumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis.

Francesco MannavolaMarco TucciClaudia FeliciAnna PassarelliStella D'OronzoFrancesco Silvestris
Published in: Journal of translational medicine (2019)
Our data correlated the osteotropism of melanoma cells to the activation of the SDF-1/CXCR4/CXCR7 axis following the exposition of tumor cells to bone-derived soluble factors. Also, we demonstrated in vitro that tumor-derived Exos can reprogram the innate osteotropism of melanoma cells by up-regulating membrane CXCR7. These results may have a potential translation to future identification of druggable targets for the treatment of skeletal metastases from malignant melanoma.
Keyphrases
  • cell migration
  • immune response
  • stem cells
  • mesenchymal stem cells
  • signaling pathway
  • bone mineral density
  • risk assessment
  • electronic health record