Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer.
Maxime GuéguinouSajida IbrahimJérôme BourgeaisAlison RobertTrayambak PathakXuexin ZhangDavid CrottèsJacques DupuyDavid TernantValérie MonbetRoseline GuibonHector Flores-RomeroAntoine LefèvreStéphanie LerondelAlain Le PapeJean-François DumasPhilippe G FrankAlban GiraultRomain ChautardFrançoise GuéraudAna J García-SáezMehdi OuaissiPatrick EmondOlivier SireOlivier HéraultGaëlle Fromont-HankardChristophe VandierDavid TougeronMohamed TrebakWilliam RaoulThierry LecomtePublished in: Cellular and molecular life sciences : CMLS (2022)
Our findings highlight a novel anti-tumoral mechanism of curcumin through its action on NCLX and mitochondria calcium overload that could benefit for therapeutic schedule of patients with MSI CRC.
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