Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer.
Albert RosenbergerNils MuttrayRayjean J HungDavid C ChristianiNeil E CaporasoGeoffrey LiuStig E BojesenLoic Le MarchandDemetrios AlbanesMelinda C AldrichAdonina TardonGuillermo Fernández-TardónGad RennertJohn K FieldMichael P A DaviesTriantafillos LiloglouLambertus A KiemeneyPhilip LazarusBernadette WendelAage HaugenShanbeh ZienolddinyStephen LamMatthew B SchabathAngeline S AndrewEric J DuellSusanne M ArnoldGary E GoodmanChu ChenJennifer A DohertyFiona TaylorAngela CoxPenella J WollAngela RischThomas R MuleyMikael JohanssonPaul BrennanMaria Teresa LandiSanjay S SheteChristopher I AmosHeike Bickeböllernull nullPublished in: European journal of medical research (2022)
The role of variants belonging to Wnt/AhR-pathways in lung cancer susceptibility may be underrated in main-effects association analysis. Complex interaction patterns in individuals of European descent have moderate predictive capacity for lung cancer or subgroups thereof, especially in never smokers.