Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study.

Stephen MilneXuan LiAna I Hernandez CorderoChen Xi YangMichael H ChoTerri H BeatyIngo RuczinskiNadia N HanselYohan BosséCorry-Anke BrandsmaDon D SinMaen Obeidat

Published in: Thorax (2020)

We have identified several novel genetic variants associated with serum CC-16 level in COPD cohorts. These genetic associations suggest a potential causal effect of serum CC-16 on the risk of having COPD and its progression, the biological basis of which warrants further investigation.

Keyphrases

chronic obstructive pulmonary disease
lung function
single cell
genome wide
cystic fibrosis
air pollution
stem cells
copy number
mesenchymal stem cells